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. 2020 Dec 9;13(2):2198–2211. doi: 10.18632/aging.202234

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Copyright: © 2021 Deng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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MiR-198 was down-expressed in glioma and its overexpression inhibited the progression of TMZ-resistant glioma cells. (A, B) Analysis of the relative expression of miR-198 in glioma tissues, glioma cells (U138 and LN18) and TMZ-resistant glioma cells (U138/TMZ and LN18/TMZ). (C) The viability of U138/TMZ and LN18/TMZ cells transfected with miR-198 mimic was detected by CCK-8 assay. (D) Proliferation of U138/TMZ and LN18/TMZ cells was determined by colony formation assays. (E) Apoptotic rate in U138/TMZ and LN18/ TMZ cells was detected by flow cytometry. (F) The TMZ resistance of U138/TMZ and LN18/TMZ cells was measured by CCK-8 assay. *P < 0.05, **P < 0.01, ***P < 0.001.