Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 9;13(2):2198–2211. doi: 10.18632/aging.202234

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © 2021 Deng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PMC Copyright notice

Circ_0005198 functioned via negatively regulating miR-198 expression. (A) MiR-198 expression in U138/TMZ and LN 18/TMZ cells was detected by qRT-PCR after transfection with miR-138 inhibitor. (B) qRTPCR was performed to detect miR-198 expression in U138/TMZ and LN18/TMZ cells after co-transfected with sicirc_0005198-2 and miR-198 inhibitor. (C, D) The viability of U138/TMZ and LN18/TMZ cells co-transfected with si-circ_0005198-2 and miR-198 inhibitor was detected by CCK-8 and colony formation assays. (E) Apoptotic rate in U138/TMZ and LN18/TMZ cells was detected by flow cytometry. (F) The TMZ resistance of U138/TMZ and LN18/TMZ cells was measured by CCK-8 assay. *P < 0.05, **P < 0.01, ***P < 0.001.