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. 2020 Dec 9;13(2):2198–2211. doi: 10.18632/aging.202234

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Copyright: © 2021 Deng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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TRIM14 was up-expressed in glioma and its silencing inhibited the progression of TMZ-resistant glioma cells. (A, B) Analysis of the relative expression of TRIM14 in glioma tissues, glioma cells (U138 and LN18) and TMZ-resistant glioma cells (U138/TMZ and LN18/TMZ). (C) qRT-PCR was used to measure the expression of TRIM14 in U138/TMZ and LN18/TMZ cells transfected with si-TRIM14. (D, E) The viability was detected by CCK-8 and colony formation assays in transfected cells. (F) Apoptotic rate was detected by flow cytometry. (G) The TMZ resistance of cells was measured by CCK-8 assay. *P < 0.05, **P < 0.01, ***P < 0.001.