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. 2020 Dec 9;13(2):2198–2211. doi: 10.18632/aging.202234

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Copyright: © 2021 Deng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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MiR-198 mediated the regulatory effects of TRIM14 on the progression of TMZ-resistant glioma cells. (A) Western Blotting analysis was used to measure TRIM14 expression in U138/TMZ and LN18/TMZ cells after co-transfected with miR-198 mimic and TRIM14 overexpression plasmid (pc-TRIM14). (B, C) The viability of U138/TMZ and LN18/TMZ cells co-transfected with miR-198 mimic and pc-TRIM14 was detected by CCK-8 and colony formation assays. (D) Apoptotic rate was detected by flow cytometry. (E) The TMZ resistance of cells was measured by CCK-8 assay. *P < 0.05, **P < 0.01, ***P < 0.001.