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. 2021 Jan 17;13(2):2912–2940. doi: 10.18632/aging.202410

Table 2. The targets information of Epimedium.

UniProt-ID Protein names Gene names Degree Species
P03372 Estrogen receptor ESR1 14 homo sapiens
P10275 Androgen receptor AR 14 homo sapiens
Q92731 Progesterone receptor ESR2 12 homo sapiens
P37231 Peroxisome proliferator activated receptor gamma PPARG 11 homo sapiens
P35354 Prostaglandin G/H synthase 2 PTGS2 11 homo sapiens
Q9UNQ0 ATP-binding cassette sub-family G member 2 ABCG2 10 homo sapiens
P49841 Glycogen synthase kinase-3 beta GSK3B 10 homo sapiens
Q16678 Cytochrome P450 1B1 CYP1B1 10 homo sapiens
P23219 Prostaglandin G/H synthase 1 PTGS1 9 homo sapiens
P11309 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 9 homo sapiens
P35228 Nitric oxide synthase, inducible NOS2 8 homo sapiens
Q16539 Mitogen-activated protein kinase 14 MAPK14 8 homo sapiens
P24941 Cell division protein kinase 2 CDK2 8 homo sapiens
P47989 Xanthine dehydrogenase/oxidase XDH 8 homo sapiens
P16220 Cyclic AMP-responsive element-binding protein 1, CREB-1, cAMP-responsive element-binding protein 1 CREB1 7 homo sapiens
P53355 Death-associated protein kinase 1 DAPK1 7 homo sapiens
P60568 Interleukin-2 IL2 7 homo sapiens
P51812 Death-associated protein kinase 1 RPS6KA3 7 homo sapiens
P08183 Multidrug resistance protein 1 ABCB1 7 homo sapiens
P15692 Vascular endothelial growth factor A VEGFA 6 homo sapiens
P15121 Aldo-keto reductase family 1 member B1 AKR1B1 6 homo sapiens
P33527 ATP-binding cassette sub-family C member 1 ABCC1 6 homo sapiens
P09917 Arachidonate 5-lipoxygenase ALOX5 5 homo sapiens
P06401 Progesterone receptor PGR 4 homo sapiens
P00918 Carbonic anhydrase 2 CA2 4 homo sapiens
P11511 Aromatase CYP19A1 4 homo sapiens
P11473 Vitamin D3 receptor VDR 4 homo sapiens
P29474 Nitric-oxide synthase, endothelial NOS3 4 homo sapiens
P07550 Beta-2 adrenergic receptor ADRB2 4 homo sapiens
P02766 Transthyretin TTR 4 homo sapiens
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH2 4 homo sapiens
Q08828 Adenylate cyclase type 1 ADCY1 3 homo sapiens
P00915 Carbonic anhydrase 1 CA1 3 homo sapiens
Q07973 1,25-dihydroxyvitamin D (3) 24-hydroxylase, mitochondrial CYP24A1 3 homo sapiens
O15439 Multidrug resistance-associated protein 4 ABCC4 3 homo sapiens
P51449 Nuclear receptor ROR-gamma RORC 3 homo sapiens
Q12772 Sterol regulatory element-binding protein 2 SREBF2 3 homo sapiens
P02774 Vitamin D-binding protein GC 3 homo sapiens
P48736 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform PIK3CG 3 homo sapiens
P04798 Cytochrome P450 1A1 CYP1A1 3 homo sapiens
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 3 homo sapiens
P08709 Coagulation factor VII F7 3 homo sapiens
Q9UBM7 7-dehydrocholesterol reductase DHCR7 2 homo sapiens
P04150 Glucocorticoid receptor NR3C1 2 homo sapiens
P07451 Carbonic anhydrase 3 CA3 2 homo sapiens
Q09472 Histone acetyltransferase p300 EP300 2 homo sapiens
Q12791 Calcium-activated potassium channel subunit alpha-1 KCNMA1 2 homo sapiens
P05091 Aldehyde dehydrogenase, mitochondrial ALDH2 2 homo sapiens
Q04206 Transcription factor p65 RELA 2 homo sapiens
P27695 DNA - (apurinic or apyrimidinic site) lyase APEX1 2 homo sapiens
Q9UHC3 Acid-sensing ion channel 3 ASIC3 2 homo sapiens
P09382 Galectin-1 LGALS3 2 homo sapiens
P14679 Tyrosinase TYR 2 homo sapiens
P05230 Fibroblast growth factor 1 FGF1 1 homo sapiens
P21554 Cannabinoid receptor 1 CNR1 1 homo sapiens
P34972 Cannabinoid receptor 2 CNR2 1 homo sapiens
Q13822 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 ENPP2 1 homo sapiens
P23141 Liver carboxylesterase 1 CES1 1 homo sapiens
P15090 Fatty acid-binding protein, adipocyte FABP4 1 homo sapiens
P17252 Protein kinase C alpha type, PKC-A, PKC-alpha PRKCA 1 homo sapiens
P47712 Cytosolic phospholipase A2, cPLA2 PLA2G4A 1 homo sapiens
Q53EL6 Programmed cell death protein 4 PDCD4 1 homo sapiens
O95136 Sphingosine 1-phosphate receptor 2, S1P receptor 2, S1P2 S1PR2 1 homo sapiens
P08842 Steryl-sulfatase STS 1 homo sapiens
O60603 Toll-like receptor 2 TLR2 1 homo sapiens
Q8NER1 Transient receptor potential cation channel subfamily V member 1 TRPV1 1 homo sapiens
P14780 Matrix metalloproteinase-9 MMP9 1 homo sapiens
P05412 Transcription factor AP-1 JUN 1 homo sapiens
P00338 L-lactate dehydrogenase A chain, LDH-A LDHA 1 homo sapiens
Q9UDY8 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 MALT1 1 homo sapiens
Q16790 Carbonic anhydrase 9 CA9 1 homo sapiens
P05177 Cytochrome P450 1A2 CYP1A2 1 homo sapiens
P28702 Retinoic acid receptor RXR-beta RXRB 1 homo sapiens
P35367 Histamine H1 receptor HRH1 1 homo sapiens
Q15788 Nuclear receptor coactivator 1 NCOA1 1 homo sapiens
P15559 NAD(P)H dehydrogenase [quinone] 1 NQO1 1 homo sapiens
P22460 Potassium voltage-gated channel subfamily A member 5 KCNA5 1 homo sapiens
P08913 Alpha-2A adrenergic receptor ADRA2A 1 homo sapiens
P08908 5-hydroxytryptamine receptor 1A, 5-HT-1A, 5-HT1A HTR1A 1 homo sapiens
P18089 Alpha-2B adrenergic receptor ADRA2B 1 homo sapiens
Q15822 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 1 homo sapiens
P14416 D (2) dopamine receptor DRD2 1 homo sapiens
P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 1 homo sapiens
P30532 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 1 homo sapiens
Q9Y271 Cysteinyl leukotriene receptor 1 CYSLTR1 1 homo sapiens
O43570 Carbonic anhydrase 12 CA12 1 homo sapiens
P78527 DNA-dependent protein kinase catalytic subunit, DNA-PK catalytic subunit, DNA-PKcs PRKDC 1 homo sapiens
P02787 Serotransferrin, Transferrin TF 1 homo sapiens
Q9NYY3 Serine/threonine-protein kinase PLK2 PLK2 1 homo sapiens