Table 3. Univariate and multivariate Cox analyses of prognostic variables in HCC patients.

Clinicopathologic characteristics	Univariable analysis*		Multivariable analysis*
	HR (95%CI)	P value	HR (95%CI)	P value
Tumor size	2.539(1.366~4.717)	0.003	2.521(1.305~4.872)	0.006
Serum AFP level	2.631(1.420~4.876)	0.002	2.366(1.270~4.407)	0.007
Tumor nodule number	1.864(0.948~3.663)	0.071
Microscopic vascular invasion	2.389(1.291~4.420)	0.006
Edmondson-Steiner grade	2.068(1.070~3.994)	0.031	2.654(1.318~5.341)	0.006
Distant metastasis	2.637(0.938~7.410)	0.066
SPATS2 up-regulation	1.285(1.121~1.474)	<0.001	1.302(1.115~1.521)	0.001

*Cox regression model was used in the analyses;

HR, Hazards ratio; CI, confidence interval.