Table 2C. Age-associated differential methylation in the fetal and adult lung tissue datasets.
| Fetal lung | Adult lung | ||||||||||
| CG site | CHR | MAPINFO | UCSC Gene | Context | Avebeta | Coef | Adjusted P | AveBeta | Coef | Adjusted P | Direction |
| cg22296612 | 6 | 15,457,699 | JARID2 | Body | 0.92 | 0.002 | 3.60E-15 | 0.99 | -0.0001 | 0.016 | +- |
| cg17110767 | 1 | 243,637,966 | SDCCAG8 | Body | 0.67 | 0.003 | 4.24E-13 | 0.97 | 0.001 | 0.014 | ++ |
| cg20801476 | 7 | 27,281,465 | EVX1 | TSS1500 | 0.06 | 0.001 | 5.27E-13 | 0.24 | 0.001 | 0.048 | ++ |
| cg20580088 | 14 | 62,161,583 | HIF1A | TSS1500 | 0.13 | 0.001 | 2.28E-12 | 0.28 | 0.002 | 0.012 | ++ |
| cg17611674 | 10 | 8,094,431 | FLJ45983 | Body | 0.10 | 0.001 | 2.34E-12 | 0.38 | 0.002 | 0.020 | ++ |
| cg24388061 | 8 | 141,249,678 | TRAPPC9 | Body | 0.73 | 0.002 | 7.82E-12 | 0.94 | 0.001 | 0.008 | ++ |
| cg21595709 | 19 | 15,344,186 | EPHX3 | TSS1500 | 0.05 | 0.001 | 2.90E-11 | 0.21 | 0.001 | 0.039 | ++ |
| cg00484358 | 1 | 110,610,995 | ALX3 | Body | 0.12 | 0.001 | 1.07E-10 | 0.38 | 0.001 | 0.039 | ++ |
| cg27583307 | 2 | 200,320,750 | SATB2 | Body | 0.03 | 0.000 | 2.35E-10 | 0.11 | 0.001 | 0.049 | ++ |
| cg03470772 | 4 | 85,503,328 | CDS1 | TSS1500 | 0.03 | 0.000 | 4.48E-10 | 0.26 | 0.002 | 0.028 | ++ |
| cg20992114 | 4 | 111,542,825 | PITX2 | Body | 0.08 | 0.001 | 7.98E-10 | 0.28 | 0.001 | 0.002 | ++ |
| cg07247419 | 20 | 21,376,484 | NKX2-4 | 3'UTR | 0.02 | 0.000 | 1.45E-09 | 0.24 | 0.002 | 0.007 | ++ |
| cg22197050 | 2 | 63,276,183 | LOC100132215 | TSS1500 | 0.03 | 0.000 | 5.83E-09 | 0.27 | 0.002 | 0.000 | ++ |
| cg06306198 | 3 | 147,128,998 | ZIC1 | Body | 0.05 | 0.001 | 1.73E-08 | 0.23 | 0.001 | 0.042 | ++ |
| cg11814235 | 18 | 28,621,490 | DSC3 | Body | 0.02 | 0.000 | 1.97E-08 | 0.12 | 0.001 | 0.031 | ++ |
| cg14614094 | 9 | 133,567,903 | EXOSC2 | TSS1500 | 0.36 | 0.001 | 3.80E-08 | 0.69 | 0.002 | 0.015 | ++ |
| cg15110296 | 12 | 12,509,705 | LOH12CR1 | TSS1500 | 0.68 | -0.002 | 5.41E-08 | 0.26 | -0.003 | 0.042 | -- |
| cg18431640 | 13 | 100,637,191 | ZIC2 | Body | 0.03 | 0.000 | 1.45E-07 | 0.19 | 0.001 | 0.008 | ++ |
| cg24719321 | 11 | 122,850,490 | BSX | Body | 0.02 | 0.000 | 1.53E-07 | 0.18 | 0.002 | 0.002 | ++ |
| cg08376141 | 6 | 32,116,591 | PRRT1 | 3'UTR | 0.11 | 0.001 | 2.11E-07 | 0.53 | 0.003 | 0.003 | ++ |
Top 20 annotated and differentially methylated age-associated DMPs overlapping between fetal lung and the adult lung tissue dataset. P-values were adjusted by the Benjamini-Hochberg method and are sorted based on the discovery fetal lung dataset.
Abbreviations: UCSC, The University of California Santa Cruz; Coef, regression coefficient - Adjusted mean difference (per day increase or decrease for fetal lung dataset and per year increase or decrease for adult lung tissue dataset) in methylation with age. NA: un-annotated CpG site; CHR, chromosome; AveBeta, average beta; P, p-value.