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. 2020 Dec 15;13(2):2049–2072. doi: 10.18632/aging.202201

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Copyright: © 2020 Yuan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Schematic diagram depicting the potential function of FGL2 in ESCA. M2-like TAMs recruit infiltrating immune cells by upregulating FGL2, producing a microenvironment that promotes the occurrence and development of ESCA. FGL2 levels correlate with infiltrating immune cell levels, and FGL2 promotes immune escape in the esophageal cancer microenvironment. This study has provided new targets for the development of tumor immunotherapies that treat ESCA by reversing the polarization of TAMs into M1-like TAMs.