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. 2020 Dec 15;13(2):2049–2072. doi: 10.18632/aging.202201

Table 1. Functional roles of FGL2, ERI1 and WNT5B.

Gene symbol Full name Function
FGL2 Fibrinogen-like 2 This protein was cloned from cytotoxic T lymphocytes and showed 36% homology to fibrinogen β and γ chains, a member of the fibrinogen super family. It is a pleiotropic cytokine that impacts diverse cellular functions.
ERI1 Exoribonuclease 1 RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. Also, able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi).
WNT5B Wnt-family member 5B This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse WNT5B protein and the human WNT5A protein, respectively. These proteins have been implicated in oncogenesis and in several developmental processes.