Table 1. Functional roles of FGL2, ERI1 and WNT5B.
Gene symbol | Full name | Function |
FGL2 | Fibrinogen-like 2 | This protein was cloned from cytotoxic T lymphocytes and showed 36% homology to fibrinogen β and γ chains, a member of the fibrinogen super family. It is a pleiotropic cytokine that impacts diverse cellular functions. |
ERI1 | Exoribonuclease 1 | RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. Also, able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). |
WNT5B | Wnt-family member 5B | This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse WNT5B protein and the human WNT5A protein, respectively. These proteins have been implicated in oncogenesis and in several developmental processes. |