Table 2. Correlation analysis between FGL2 and related immune cell genes and markers using TIMER.
| Description | Gene markers | ESCA | |||
| None | Purity | ||||
| Cor | P | Cor | P | ||
| Monocyte | CD86 | 0.683 | *** | 0.637 | *** |
| CD115 (CSF1R) | 0.779 | *** | 0.752 | *** | |
| CD14 | 0.553 | *** | 0.489 | *** | |
| TAM | CD68 | 0.328 | *** | 0.269 | ** |
| IL10 | 0.522 | *** | 0.479 | *** | |
| CCL2 | 0.578 | *** | 0.532 | *** | |
| M1 Macrophage | IRF5 | 0.058 | 0.431 | 0.015 | 0.84 |
| INOS (NOS2) | -0.06 | 0.419 | -0.029 | 0.696 | |
| COX2 (PTGS2) | 0.13 | 0.03 | 0.135 | 0.071 | |
| M2 Macrophage | CD163 | 0.66 | *** | 0.616 | *** |
| VSIG4 | 0.647 | *** | 0.604 | *** | |
| MS4A6A | 0.727 | *** | 0.687 | *** | |
| Treg | FOXP3 | 0.663 | *** | 0.621 | *** |
| CCR8 | 0.662 | *** | 0.622 | *** | |
| STAT5B | 0.395 | *** | 0.431 | *** | |
| CD4 | 0.778 | *** | 0.744 | *** | |
| T cell exhaustion | PD-1 (PDCD1) | 0.647 | *** | 0.597 | *** |
| CTLA4 | 0.646 | *** | 0.588 | *** | |
| LAG3 | 0.602 | *** | 0.554 | *** | |
| TIM-3(HAVCR2) | 0.753 | *** | 0.718 | *** | |
| GZMB | 0.531 | *** | 0.462 | *** | |
| CD8+ T cell | CD8A | 0.634 | *** | 0.585 | *** |
| CD8B | 0.583 | *** | 0.54 | *** | |
| T cell (general) | CD3D | 0.609 | *** | 0.54 | *** |
| CD3E | 0.642 | *** | 0.574 | *** | |
| CD2 | 0.662 | *** | 0.606 | *** | |
| B cell | CD19 | 0.356 | *** | 0.248 | ** |
| CD79A | 0.427 | *** | 0.333 | *** | |
| Neutrophils | CD66b(CEACAM8) | 0.028 | 0.707 | -0.008 | 0.91 |
| CD11b (ITGAM) | 0.488 | *** | 0.421 | *** | |
| CCR7 | 0.515 | *** | 0.435 | *** | |
| Natural killer cell | KIR2DL1 | 0.271 | ** | 0.192 | * |
| KIR2DL3 | 0.302 | *** | 0.278 | ** | |
| KIR2DL4 | 0.394 | *** | 0.342 | *** | |
| KIR3DL1 | 0.281 | ** | 0.224 | * | |
| KIR3DL2 | 0.22 | * | 0.153 | 0.039 | |
| KIR3DL3 | -0.04 | 0.59 | -0.041 | 0.581 | |
| KIR2DS4 | 0.2 | * | 0.183 | 0.014 | |
| Dendritic cell | HLA-DPB1 | 0.688 | *** | 0.635 | *** |
| HLA-DQB1 | 0.424 | *** | 0.35 | *** | |
| HLA-DRA | 0.604 | *** | 0.548 | *** | |
| HLA-DPA1 | 0.668 | *** | 0.623 | *** | |
| BDCA-1(CD1C) | 0.576 | *** | 0.499 | *** | |
| BDCA-4(NRP1) | 0.624 | *** | 0.595 | *** | |
| CD11c (ITGAX) | 0.626 | *** | 0.55 | *** | |
| Th1 | T-bet (TBX21) | 0.638 | *** | 0.568 | *** |
| STAT4 | 0.672 | *** | 0.61 | *** | |
| STAT1 | 0.437 | *** | 0.399 | *** | |
| IFN-γ (IFNG) | 0.519 | *** | 0.462 | *** | |
| TNF-α (TNF) | 0.165 | 0.025 | 0.106 | 0.155 | |
| Th2 | GATA3 | 0.372 | *** | 0.311 | *** |
| STAT6 | 0.081 | 0.273 | 0.113 | 0.131 | |
| IL13 | 0.324 | *** | 0.245 | ** | |
| STAT5A | 0.405 | *** | 0.37 | *** | |
| IL2RA (CD25) | 0.649 | *** | 0.606 | *** | |
| IL2RB (CD122) | 0.687 | *** | 0.648 | *** | |
| Tfh | BCL6 | 0.197 | * | 0.2 | * |
| IL21 | 0.252 | ** | 0.188 | 0.012 | |
| Th17 | STAT3 | 0.226 | * | 0.203 | * |
| IL17A | -0.009 | 0.907 | -0.008 | 0.919 | |
| IL6 | 0.352 | *** | 0.307 | *** | |
Th, T helper cell; Tfh, T follicular helper cell; Treg, T regulatory cell; Cor, R value of Spearman’s correlation; None, correlation without adjustment; Purity, correlation adjusted by purity. * P < 0.01; ** P < 0.001; *** P < 0.0001.