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. 2020 Dec 9;13(2):2397–2417. doi: 10.18632/aging.202269

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Copyright: © 2020 Fan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Screening of differentially expressed genes based on protein-protein interaction (PPI) and Univariate Cox regression analysis. (A) PPI network of the aberrantly expressed genes based on STRING (interaction confidence value > 0.95). (B) Visualized PPI analysis of differentially expressed genes using Cytoscape. (C) Top 30 genes with maximum adjacent nodes. (D) Univariate Cox regression analysis for the aberrantly expressed genes. Genes with a p value less than 0.05 are shown in the forest plot. (E) Venn diagram of key genes in PPI and Cox regression analysis. Four TIIC-related genes (CCR2, CCR4, P2RY12, and P2RY13) were finally screened as prognostic factors of LUAD.