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. 2021 Feb 15;131(4):e139542. doi: 10.1172/JCI139542

Figure 7. Inhibition of IDH1-R132H in combination with SOC and αPD-L1 induces tumor antigen–specific CD8 T cell responses within mIDH1 glioma TME.

Figure 7

(A) Experimental design to characterize T cells in the TME of mIDH1-OVA glioma–bearing mice after treatment. (B) Tumor-specific CD8+ T cells within the TME of mIDH1-OVA tumors were analyzed by staining with the SIINFEKL-Kb tetramer. Representative flow plots for each treatment are displayed. **P < 0.01; ***P < 0.001, 1-way ANOVA. (C) Activation status of CD8+ T cells within the TME of mIDH1-OVA tumors was analyzed by staining for IFN-γ after TME stimulation with the tumor cell lysate. **P < 0.01; ***P < 0.001, 1-way ANOVA. Bars represent mean ± SEM (n = 5 biological replicates).