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. 2021 Feb 15;131(4):e139542. doi: 10.1172/JCI139542

Figure 9. Inhibition of IDH1-R132H in combination with SOC and αPD-L1 decreases the accumulation of M2 macrophages in TME of mIDH1 glioma.

Figure 9

(A) Experimental design to characterize macrophages in the TME of mIDH1-OVA glioma–bearing mice after treatment. (B) The percentage of M1 (F480+/CD206–) and M2 (F480+/CD206+) macrophages within the CD45+ cell population in the TME of saline-, AGI-5198+IR–, or AGI-5198+SOC+αPD-L1–treated glioma-bearing mice was assessed at 27 dpi. Representative flow plots for each group are displayed. *P < 0.05; ****P < 0.0001, 1-way ANOVA. Bars represent mean macrophage quantification ± SEM (n = 5 biological replicates).