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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: FASEB J. 2021 Mar;35(3):e21386. doi: 10.1096/fj.202002071R

Figure 4: Downstream targets of individual BMPR1s reflect functional divergence of BMPR1s in ECs.

Figure 4:

(A) GO term analyses identified each BMPR1CA activates a unique set of transcripts in HUVECs. While expression of any BMPR1CA could induce transcriptional activation of genes associated with TGFβ signaling and angiogenesis in HUVECs, expression of ALK1CA additionally increased the transcription of IFNγ signaling or KRAS signaling associated genes, and expression of ALK2CA led to activation of genes implicated in epithelial to mesenchymal transition. (B-D) Gene network enrichment analyses showed ALK1CA (B), ALK2CA (C), or ALK3CA (D) upregulated a specific set of genes in HUVECs.