. 2021 Jan 8;23(3):902–907. doi: 10.1021/acs.orglett.0c04116

Table 1. Comparison of Melting Temperatures for Unmodified and “Chiral Box” PNAs with Full-Matched and Mismatched Target DNA. ΔT_m = T_m(Full Match) – T_m(Mismatch).

Hybrid type	DNA	T_m [°C]	ΔT_m [°C]
PNA 1	DNA1-FM	76.7 ± 0.9	14.1
PNA 1	DNA1-MM	62.6 ± 0.6	14.1
PNA 2	DNA1-FM	72.4 ± 0.8	15.7
PNA 2	DNA1-MM	56.7 ± 0.8	15.7
PNA 3	DNA1-FM	73.0 ± 2.0	15.0
PNA 3	DNA1-MM	58.0 ± 0.9	15.0
PNA 4	DNA2-FM	65.9 ± 0.5	15.9
PNA 4	DNA2-MM	50.0 ± 0.5	15.9
PNA 5	DNA2-FM	59.9 ± 0.2	19.2
PNA 5	DNA2-MM	40.7 ± 0.5	19.2

Table 1. Comparison of Melting Temperatures for Unmodified and “Chiral Box” PNAs with Full-Matched and Mismatched Target DNA. ΔTm = Tm(Full Match) – Tm(Mismatch).