TABLE 3.

International Classification of Retinopathy of Prematurity Treatment and Follow-Up Guidelines

Treatment recommended

1. Zone I ROP at any stage with plus disease

2. Zone I ROP stage 3 without plus disease

3. Zone II stage 2 or 3 with plus disease

Follow-up examination interval

1 week or less

Zone I: immature retina, stage 1 or 2 ROP

Zone II: stage 3 ROP

Presence or suspected presence of APROP

1–2 weeks

Zone I: unequivocally regressing ROP

Posterior zone II: immature retina

Zone II: stage 2 ROP

2 weeks

Zone II: immature retina, stage 1 ROP, unequivocally regressing ROP

2–3 weeks

Zone II: stage 1 ROP

Zone III: stage 1 or 2 ROP, regressing ROP

Screening is discontinued if the following are present

1. Zone III vascularization without previous zone I or II disease

2. 360 degrees of full retinal vascularization

3. Postmenstrual age of 50 weeks without prethreshold disease

4. Regression of ROP in zone III without abnormal vascular tissue that can reactivate in zones II or III