Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Biosynthesis and chemical properties of pseudouridine. The isomerization of uridine to pseudouridine is performed by either standalone pseudouridine synthases (PUSs) or H/ACA snoRNP complexes containing the catalytic component dyskerin (DKC1), additional core proteins (NOP10, GAR1 and NHP2) and an H/ACA snoRNA which serves as a guide. Uridine can accept (A) and donate (D) one hydrogen bond (gray dashed arrow) each whereas pseudouridine can donate an additional hydrogen bond.
