Table 3.
Contrasts
| Contrasts differences between groups (P peak voxel) | Areas with significant Z-value threshold 0.05 |
|---|---|
| FA aTBI < control** (0.003) | CC (genu, body, splenium); fornix (column, body); retrolenticular internal capsule R, L; ant corona radiata R, L; sup corona radiata R, L; post corona radiata R, L; post thalamic radiationa R, L; sagittal stratumb R, L; external capsule R, L; cingulum (cingulate gyrus) R, L; fornix (cres) / stria terminalis R, L; sup long fasc R, L; uncinate fasc R, L; tapetum R |
| MD aTBI > control* (0.04) | Ant corona radiata L; sagittal stratumb R; external capsule R |
| Contrasts differences between subgroups | |
| FA VA+ < control* (0.02) | CC (genu, body, splenium); ant limb internal capsule R; ant corona radiata R, L; sup corona radiata R, L; post corona radiata R; post thalamic radiationa R; sagittal stratumb R; external capsule R, L; fornix (cres) / stria terminalis R; sup long fasc R, L; sup front-occ fasc R; uncinate fasc R |
| MD VA+ > control* (0.03) | Sagittal stratumb R |
| FA VA- < control* (0.02) | CC (genu, body, splenium); ant corona radiata R, L; sup corona radiata R, L; post corona radiata L; sagittal stratumb R, L; external capsule R, L; cingulum (cingulate gyrus) L; sup long fasc R, L; uncinate fasc R, L |
| FA impaired balance aTBI < control** (0.001) | CC (genu, body, splenium); fornix (column, body); cerebral peduncle R; ant limb internal capsule L; post limb internal capsule R; retrolenticular internal capsule R, L; ant corona radiata R, L; sup corona radiata R, L; post corona radiata R, L; post thalamic radiationa R, L; sagittal stratumb R, L; external capsule R, L; cingulum (cingulate gyrus) R; fornix (cres) / stria terminalis R, L; sup long fasc R, L; uncinate fasc R, L; tapetum R |
| MD impaired balance aTBI > control** (0.008) | CC (genu, body, splenium); ant limb internal capsule R, L; retrolenticular internal capsule R, L; ant corona radiata R, L; sup corona radiata R, L; post corona radiata R, L; post thalamic radiationa R, L; sagittal stratumb R, L; external capsule R, L; fornix (cres) / stria terminalis R, L; sup long fasc R, L; sup front-occ fasc R; uncinate fasc R, L; tapetum R, L |
| FA impaired balance aTBI < preserved balance aTBI* (0.04) | CC (genu); ant corona radiata L |
| MD impaired balance aTBI > preserved balance aTBI* (0.03) | CC (genu); ant corona radiata L; external capsule L |
| Whole brain correlation contrasts | |
| Vestibular-mediated balance | |
| All participants FA to balance (−)** (0.005) | CC (genu, body, splenium); fornix (column, body); cerebral peduncle R, L; ant limb internal capsule R; post limb internal capsule R, L; retrolenticular internal capsule R, L; ant corona radiata R, L; sup corona radiata R, L; post corona radiata R, L; post thalamic radiationa R, L; sagittal stratumb R, L; external capsule R, L; cingulum (cingulate gyrus) R; fornix (cres) / stria terminalis R, L; sup long fasc R, L; sup front-occ fasc R; uncinate fasc R; tapetum R, L |
| All participants MD to balance (+)* (0.02) | CC (genu, body, splenium); ant limb internal capsule R, L; retrolenticular internal capsule R, L; ant corona radiata R, L; sup corona radiata R, L; post corona radiata R, L; post thalamic radiationa R, L; sagittal stratumb R, L; external capsule R, L; fornix (cres) / stria terminalis R, L; sup long fasc R, L; sup front-occ fasc R; uncinate fasc R; tapetum R, L |
| aTBI FA to balance (−)* (0.04) | CC (genu, body, splenium); cerebral peduncle R; post limb internal capsule R; retrolenticular internal capsule R; ant corona radiata R, L; sup corona radiata R; post corona radiata R; post thalamic radiationa R; sagittal stratumb R; external capsule R; sup long fasc R; tapetum R |
| aTBI MD to balance (+)* (0.04) | CC (splenium); retrolenticular internal capsule R; sup corona radiata R; post corona radiata R, L; post thalamic radiationa R; sagittal stratumb R; external capsule R; fornix (cres) / stria terminalis R; sup long fasc R, L |
| VA+ MD to balance (+) (0.063) | # Post thalamic radiationa R; #sagittal stratumb R; #external capsule R |
| Vestibular-perceptual thresholds | |
| All participants MD to VPT (+)* (0.04) | Sagittal stratumb R |
| Impaired balance aTBI FA to VPT (−) (0.07) | $ Post thalamic radiationa R; $sagittal stratumb R |
| Impaired balance aTBI MD to VPT (+)* (0.05) | Sagittal stratumb R |
| Vestibular-ocular reflex thresholds | |
| Impaired balance aTBI FA to VOR (−)* (0.02) | CC (genu, body, splenium); ant limb internal capsule R; retrolenticular internal capsule R; ant corona radiata R; sup corona radiata R; post corona radiata R; post thalamic radiationa R; sagittal stratumb R; external capsule R; Fornix (cres) / stria terminalis R; sup long fasc R; sup front-occ fasc R; uncinate fasc R |
| Impaired balance aTBI MD to VOR (+)** (0.007) | Retrolenticular internal capsule R; sagittal stratumb R; external capsule R |
−/+ = negative/positive correlation contrast between DTI parameter and behavioural measure; ant = anterior; CC = corpus callosum; fasc = fasciculus; front-occ = fronto-occipital; L = left; long = longitudinal; post = posterior; R = right; sup = superior; VA+/− = patients with/without vestibular agnosia; VPT = vestibular-perceptual thresholds.
a
Post thalamic radiation, includes optic radiation.
b
Sagittal stratum, includes inferior longitudinal fasciculus and inferior front-occipital fasciculus.
*
P < 0.05.
**
P < 0.01.
#
Tendency, threshold set at 0.065.
$
Tendency, threshold set at 0.075.