Figure 4. Arterial transit time (ATT) measurements acquired in the mid-brain of 12 months old wild-type (WT) and transgenic Swedish Dutch Iowa (Tg-SwDI) mice.

On the top row, measurements acquired at baseline are displayed, on the bottom row measurements acquired while administering 7.5% CO₂. On the left column, graphs display the measured arterial spin labeling (ASL) signal (mean ± standard deviation) plotted against increasing post-label delay times. In the middle, maps are displayed that show averaged arrival times of the ASL signal. The maps were acquired in a mid-brain slice and are averaged for WT (top) and Tg-SwDI mouse (bottom). On the right, boxplot representations of the ATT values obtained in all mice are displayed, where circles and squares represent individual mice.