Figure 5. PolyIC-induced actin reorganization was partially attenuated by RIG-I and MDA5 knockdown. F-actin representative microscopic images in human podocytes. Podocytes were transfected with non-targeting siRNA (cont si), RIG-I siRNA, or MDA5 siRNA, followed by treatment with 500 ng/ml poly IC for 24 h. At 72 h post-transfection, podocytes were fixed and stained with phalloidin to detect F-actin. Magnification 400×. Bar represents 50 μm.
