Table 2.
Chronic ventilation patients cared for in the ICU and mortality outcomes, arranged by year.
| First author, Year | Inclusion criteria - Minimum No. Days on MV | Subjects, n | Age, years∗ | Total MV Duration, days∗ |
Mortality N, (%) |
|---|---|---|---|---|---|
| Cohen, 1993 [28] | 2 | 45 | 85 (3) | 24 (31) | 35 (77.8) |
| Combes, 2003 [29] | 14 | 347 | Survivors: 63 (14) Non-survivors: 67 (13) |
37 (25) | 150 (43.2) |
| Chelluri, 2003 [27] | 2 | 813 | 60 (19) | 9 (4, 16) Md (IQR) | NR (29.0) |
| Robson, 2003 [58] | 21 | 161 | 69 (21–88) Md (range) | NR | 22 (13.7) |
| Cox, 2004 [32] | 3 | 9,794 | 62 (48, 72) Md(IQR)† | NR | 2,804 (28.6)‡ |
| Cox, 2007 [33] | 4 | 267 | 66 (45, 75) Md(IQR) | 16 (10, 24) Md (IQR) | 53 (19.9)‡ |
| 21 | 114 | 66 (47, 74) Md(IQR) | 27 (23, 36) Md (IQR) | 36 (31.6)‡ | |
| Combes, 2007 [30] | 3 | 166 | 59 (16) | 35 (25) | 55 (33.1) |
| Carson, 2008 [24] | 21 | 200 | 56 (17) | 35 (26, 51) Md (IQR) | 82 (41.0)‡ |
| Unroe, 2010 [70] | 4 or 21§ | 126 | 55 (16) | 27 (18, 27) Md (IQR) | 23 (18.3)‡ |
| Lone, 2011 [50] | 21 | 349 | 60 (15) | 33 (15) | 83 (26.2)|| |
| Kojicic, 2011 [43] | Failure to wean∗∗ | 65 | 68 (49, 80) Md(IQR) | 24 (18, 37) Md (IQR) | 19 (29.2)‡ |
| Leroy, 2014 [47] | 21 | 201 | 64 (14) | 37 (20) | 83 (41.3) |
| Li, 2016 [48] | 21 | 157 | 74 (18–103) Md (range) | 51 (21–3419) Md (range)†† | 31 (19.8) |
| Mok, 2016 [52] | 21 | 184 | 65 (19–91) Md (range) | 35 (21–160) Md (range) | 85 (46.2) |
| Hill, 2017 [42] | 21 | 11,594 | NR | NR | 4,932 (42.4)‡ |
| Roh, 2019 [59] | 21 | 302 | 63 (18–89) Mn (range) | 29 (21–199) Mn (range) | 95 (31.5) |
| Abitağaoğlu, 2019 [17] | Failure to wean | 51 | 78 (8) | 41 (23) | 13 (25.5) |
NR, not reported; MV, mechanical ventilation.
Values are presented as mean (SD) unless otherwise specified.
Cox et al. included subjects from 1993 to 2002 and presented median (IQR) age of patients per period as follows: 65 (51, 73) for 1993, 65 (49, 73) for 1997, and 62 (48, 72) for 2002.
Mortality rates reported at discharge from the acute hospital. In these studies, the number of deaths explicitly occurring in the ICU was not provided separately.
Inclusion criteria required mechanical ventilation for at least >96 h with tracheostomy or at least >21 days without tracheostomy.
Denominator used to calculate the mortality rate was 317 instead of 349.
Inclusion criteria included failure to wean or placement of tracheostomy in anticipation of long-term ventilation.
Total duration of ventilation was not provided. The median (range) of ventilation for 109/157 subjects at the start of the study was reported to be 51 (21–3419). The study duration was 28 days.