Table 3.
Chronic ventilation patients cared for in non-ICU units and mortality outcomes, arranged by year.
| First author, Year | Non-ICU unit Nomenclature | Inclusion criteria - Minimum No. Days on MV |
Subjects, n | Age, years∗ | Current MV Duration, days∗ | Mortality N, (%) |
|---|---|---|---|---|---|---|
| Krieger, 1988 [44] | Non-invasive monitoring unit | 3 | 11 | 75 (11) | 12 (9) PMV: 11 (11) |
3 (27.2) |
| Cordasco, 1991 [31] | Non-ICU ventilator care service | 7, with tracheostomy† | 99 | 21–84‡ | - | 25 (25.3) |
| Scheinhorn, 1994 [64] | Regional weaning center | NR | 421 | Weaned: 68 (1) Not weaned: 71 (1) |
58 Mn PMV: 49 Mn |
116 (27.6) |
| Latriano, 1996 [46] | Non-monitor respiratory care floor | NR | 224 | 66 (17) | 49.9 (66) PMV: 23 (19) |
111 (49.6) |
| Bagley, 1997 [19] | Ventilator weaning unit | Failure to wean | 278 | 67 (21–99) Mn (range) | - | 133 (47.8) |
| Gracey, 1997 [38] | Ventilator-dependent rehabilitation unit | 21 | 206 | 65 (14) | - PMV: 58 (72) |
16 (7.8) |
| Dasgupta, 1999 [34] | Respiratory special care unit | NR | 212 | 68 (60, 73) Md (IQR) | 13 (15, 23) Md (IQR) PMV: 25 Md |
20 (9.4) |
| Carson, 1999 [23] | Long-term acute care hospital | 14 | 133 | 71 (12) | - PMV: 25 (9–123) Md (range) |
66 (49.6) |
| Seneff, 2000 [9] | Long-term acute care facility | 21 | 1,702 | 71 Mn | - | NR (51.0) |
| Schonhofer, 2002 [66] | Respiratory intensive care unit | 14 & failure to wean | 403 | 66 (59, 71) Md (IQR) | - PMV: 33 (19, 50) Md (IQR) |
98 (24.3) |
| Stoller, 2003 [69] | Respiratory special care unit | 14–21 | 162 | 65 (14) | - | 27 (16.7) |
| Ceriana, 2003 [26] | Respiratory intensive care unit | NR | 96 | 67 (12) | - PMV: 38 (15)§ |
13 (13.5) |
| Wijkstra, 2003 [72] | Chronic assisted ventilatory care unit | Failure to wean | 50 | 46 (18–76) Mn (range) | - PMV: 0–12600‡ |
11 (22.0) |
| Pilcher, 2005 [56] | Respiratory unit | Failure to wean | 153 | 62 (49, 72) Md (IQR) | - | 42 (27.5) |
| Bigatello, 2007 [20] | Acute respiratory unit | NR | 210 | 66 (52, 75) Md (IQR) | - PMV: 21 (12, 32) Md (IQR) |
30 (14.3) |
| Scheinhorn, 2007 [65] | Long-term care hospital | NR | 1,419 | 72 (18–98) Md (range) | 21 (1–365) Md (range) PMV: 25 (0–1154) Md (range) |
353 (24.9)|| |
| Polverino 2010 [57] | Respiratory intensive care unit | 15 | 3,106 | 1991–95: 78 (1) | - | 82 (9.0) |
| 1995–00: 76 (4) | - | 138 (14.0) | ||||
| 2001–05: 73 (5) | - | 184 (15.0) | ||||
| Mamary, 2011 [51] | Ventilation rehabilitation unit | NR | 182 | 64 (16) | Total MV duration∗∗ | 35 (19.2) |
| Rose, 2012 [60] | Prolonged ventilation weaning center | 21 | 115 | 70 (59, 77) Md (IQR) | - PMV: 55 (37, 89) Md (IQR) |
15 (13.0) |
| Hannan, 2013 [40] | Ventilation weaning unit | 14 | 78 | 59 (16–85) Mn (range) | - PMV: 27 (16–36) Md (range) |
8 (10.3) |
| Fini, 2014 [35] | Multidisciplinary center | NR | 47 | 62 (13)†† | - | 10 (21.3) |
| Tsara, 2015 [10] | Respiratory intermediate unit | Failure to wean | 548 | 57 (18) | - | NR (15.0) |
| Lai, 2016 [45] | Respiratory care center | 21 | 510 | 84 (3) | - | 111 (21.8) |
| Bonnici, 2016 [22] | Specialist weaning, rehabilitation, and home MV center | 28 | 262 | 64 (53, 73) | - | 38 (14.5) |
| Hendin, 2019 [41] | Medical wards | Failure to wean | 50 | 56 (19–83) Mn (range) | - | 12 (24.0) |
| Ghiani, 2020 [37] | National weaning center | Failure to wean | 263 | 71 (11) | Total MV duration∗∗ PMV: 27 (22) |
38 (14.5) |
LOS, length of stay; MV, mechanical ventilation; NR, not reported; PMV, prior duration of mechanical ventilation.
Values are presented as mean (SD) unless otherwise specified. If the range or IQR was not stated, only the mean or median was reported.
Tracheostomy must be in place for at least one week before a subject is transferred.
Subjects were presented in subcategories; the mean (range) was reported for each subcategory. For simplified data presentation, only the range of reported values has been shown.
Length of prior mechanical ventilation was only given for 40 subjects who were admitted for weaning.
Denominator used to calculate the mortality rate was 1,414 instead of 1,419.
Total duration of mechanical ventilation since initiation was 55 (42.7) days for Mamary et al. and 52.2 (28.6) days for Ghiani et al.
Age at diagnosis of Amyotrophic Lateral Sclerosis was given. The mean time from diagnosis to invasive ventilation ranged from 799.2 to 849.3 days.