Table 4.
Chronic ventilation patients cared for at home and mortality outcomes, arranged by year.
| First author, Year | Subjects, n∗ | Age, years† | Duration of HMV, months or years† | Follow-up Period, years | Mortality N, (%) |
|---|---|---|---|---|---|
| Sivak, 1982 [67] | 21 | 59 (26–81) | 2.2 (0.1–17.0) yr | NR | 5 (23.8) |
| Fischer, 1982 [36] | 29 | 61 (31–73) | 2.4 (0.1–6.8) yr‡ | 2 | 12 (41.4) |
| Wolf, 1993 [73] | 13 | 17–78§ | 6.4 (1.0–12.0) yr | NR | 2 (15.3) |
| Moss, 1993 [53] | 19 | 57 (36–78) | 1.7 (0.3–5.8) yr | 1 | 7 (36.4) |
| Muir, 1994 [54] | 253 (41 NH) | 63 (9) | Minimum 1.0 yr|| | 6–10 | 203 (84.9)∗∗ |
| Scheinhorn, 1994 [64] | 26 | NR | Minimum 3.4 (0.2) mo†† | 1 | 14 (53.9) |
| 49 NH‡‡ | NR | 45 (91.8) | |||
| Lin, 1996 [49] | 34 | 48 (21) | 10.6 (8.7) mo | 4 mo | 5 (14.7) |
| Nugent, 1996 [55] | 13 | 36 (13–67) | 0.1–12.0 yr§§ | 1 | 2 (15.4) |
| Cazzolli, 1996 [25] | 50 (25 NH) | 60 (31–89) | 1.0–14.0 yr|||| | 7 | 23 (46.0) |
| Guber, 2002 [39] | 25 | 38 (1–72) | 1.1 (0.2–2.7) yr | 2 | 3 (12.0) |
| Salahuddin, 2005 [12] | 11 | 49 (10–98) | 9.5 (3.2–15.7) mo Mn (95% CI) | 5 | 3 (27.3) |
| Björling, 2006 [21] | 27 | 17–79¶ | Survivors: 26.0 (22.0–34.0) yr Non-survivors: 14.0 (4.0–27.0) yr |
23 | 18 (66.7) |
| 67# | 18–91¶ | NR | 10 | 11 (16.4) | |
| Vitacca, 2011 [71] | 12 | 72 (6) | NR | 1 | 4 (33.3) |
| Sancho, 2011 [63] | 38 | 65 (9) | NR | 1 | 8 (21.1) |
| Spataro, 2012 [68] | 87¶¶ | 61 (47–66) Md (range) | NR | 10 | 52 (59.8) |
| Fini, 2014 [35] | 37 (10 NH) | Home: 58## NH: 69## |
NR | 12 | 19 (51.4) |
| Rose, 2019 [61] | 52 (7 NH) | 64 (45, 75) Md (IQR) | NR | 4 | 25 (48.1) |
| Saiphoklang, 2019 [62] | 12 | 72 (18) | NR | 2–7 | 5 (41.7) |
| Aksoy, 2019 [18] | 134 | 66 (54, 73) Md (IQR) | NR | 1 | 26 (19.4) |
HMV, home mechanical ventilation; NH, nursing home; NR, not reported.
Total number of subjects. For some studies which had a few of their subjects in a nursing home or long-term care facility, the number of NH participants is stated in the parenthesis.
Values are presented as mean (SD) or mean (range) unless otherwise specified.
Duration of HMV derived from how long patients were observed.
Range. No mean or median reported.
Subjects were ventilated for at least one year. This data was derived from the study's inclusion criteria.
Denominator used to calculate the mortality rate was 239.
Subjects were ventilated for a mean duration of 3.4 months in the prior care setting. Duration of ventilation at home or long-term care facility was not provided.
Outcomes for subjects cared for at home versus subjects cared for in nursing homes were reported separately.
The range of duration of HMV based on initiation date (in years) subtracted from the year the study was conducted. HMV initiation in the same year as the study was assumed to be at least one month.
Based on the survival information provided – 8 patients lived for 1–2 years after HMV initiation while among patients alive by the end of the study, three had been living with HMV for 11–14 years.
Subjects were presented in subcategories, and the median was reported for each subcategory. For simplified data presentation, the range of actual values has been demonstrated.
Two groups of patients were studied. The first cohort was patients cared for at the formal start of the unit in 1982, while the second patient cohort was cared for in 1997. For the second cohort, only adults were included in the analysis because there was a substantial number of patients less than 18 years old.
Five subjects remained in the acute hospital and were still included in the analysis.
Mean age at diagnosis of Amyotrophic Lateral Sclerosis was given. The mean time from diagnosis to invasive ventilation ranged from 799.2 to 849.3 days.