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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: J Mol Cell Cardiol. 2020 Nov 12;151:46–55. doi: 10.1016/j.yjmcc.2020.11.002

Figure 4. m6A-modified transcripts enriched in failing human heart samples are conserved in neonatal rat cardiomyocytes cultured in hypertrophic conditions.

Figure 4.

(A) General schematic for m6A peak comparison between human failing and neonatal rat cardiomyocyte hypertrophic samples. (B) Venn diagram of transcripts containing enriched m6A peaks in failing (red) and rat hypertrophic cardiomyocytes (blue) (FC >1.5 by exomePeak). Comparison found 38 total transcripts to be co-enriched. (C) Table outlining 14 transcripts co-enriched in failing and hypertrophic samples that play roles in gene expression. Genes in bold have conserved m6A peaks at the nucleotide level. (D,E) Gene view of either REST (D) or SF3B4 (E) found to contain a conserved m6A peak enriched in both human failing (top, red) and rat hypertrophic (bottom, blue) as compared to respective controls. The enriched peak calculated by exomePeak (green) is shown in relation to the total gene (left) and in relation to the specific exon (right). Read counts are found bracketed (top right, black).