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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Neurobiol Learn Mem. 2020 Dec 16;178:107364. doi: 10.1016/j.nlm.2020.107364

Figure 1.

Figure 1.

Juvenile and adult males and adult females lacking one copy of Pcdh10 exhibit cued fear conditioning deficits. A) Juvenile Pcdh10+/− males spent a similar percentage of time freezing as their wild-type littermates during a baseline period of training and in the pre-CS period, prior to the tone cue during the 24 hr test. During the presentation of the tone cue, however, Pcdh10+/− males froze less than WT. B) Juvenile Pcdh10+/− females froze for a similar percentage of time as their wild-type littermates during the baseline period of training and the Pre-CS and CS periods of the 24 h cued fear conditioning test. C) Adult Pcdh10+/− males spent significantly less time freezing prior to and during a tone cue 24 h after training than their WT littermates. Freezing levels were not significantly different during baseline. D) Pcdh10+/− adult females exhibited more freezing behavior during a baseline period of training and significantly less time freezing 24 h later during the CS period of the cued fear conditioning test. During the Pre-CS presentation of the 24 h test, Pcdh10+/− females froze a similar amount as their wild-type littermates. *=p<0.05, **=p<0.01, ***=p<0.001.