Table 2.
Greater post-EVT white matter infarct volume independently decreased the odds of 90-day functional independence. Anterior circulation sub-region infarct volumes (white matter, cortex, basal ganglia), older age, more coronary artery disease, higher presenting NIHSS, and lower rates of TICI 2b-3 reperfusion decreased the odds of 90-day functional independence in univariable analyses. In a multivariable model including infarct volumes from each region and these other identified candidate variables, only greater post-EVT white matter infarct volume and older age independently decreased the odds of functional independence at 90-days. Abbreviations: TIA transient ischemic attack, NIHSS NIH Stroke Scale, ICA internal carotid artery, M1 first segment of middle cerebral artery, LKW last known well, TICI Thrombolysis in Cerebral Infarction, OR odds ratio, CI confidence interval.
| Univariable | Multivariable | |||
|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |
| Age, Years | 0.956 (0.932,0.980) | <0.0001 | 0.920 (0.885,0.958) | <0.0001 |
| Female | 0.792 (0.409,1.530) | 0.487 | ||
| Hypertension | 0.567 (0.282,1.141) | 0.112 | ||
| Diabetes | 0.620 (0.247,1.559) | 0.310 | ||
| Atrial Fibrillation | 0.703 (0.343,1.442) | 0.337 | ||
| Stroke/TIA History | 0.711 (0.291,1.736) | 0.454 | ||
| Coronary Disease | 0.332 (0.132,0.835) | 0.019 | 0.456 (0.141,1.472) | 0.189 |
| Smoking | 1.429 (0.610,3.346) | 0.411 | ||
| Presenting NIHSS | 0.927 (0.862,0.996) | 0.039 | 0.941 (0.848,1.045) | 0.255 |
| Cervical ICA Disease | 0.872 (0.362,2.097) | 0.759 | ||
| ICA Terminus Occlusion | 1.183 (0.504,2.775) | 0.699 | ||
| M1 Occlusion | 0.926 (0.464,1.848) | 0.827 | ||
| Alteplase | 1.377 (0.708,2.678) | 0.346 | ||
| LKW-Alteplase Time, Min | 0.998 (0.991,1.006) | 0.663 | ||
| LKW-Groin Time, Min | 1.000 (0.998,1001) | 0.447 | ||
| Groin-Recanalization Time, Min | 0.993 (0.984,1.002) | 0.147 | ||
| TICI 2b-3 | 6.243 (1.763,22.11) | 0.005 | 3.723 (0.549,25.25) | 0.178 |
| Left Side Infarct | 1.649 (0.835,3.256) | 0.150 | ||
| Bilateral Infarct | 2.059 (0.334,12.72) | 0.437 | ||
| White Matter Infarct Volume, cc | 0.953 (0.933,0.972) | <0.0001 | 0.886 (0.814,0.964) | 0.005 |
| Cortical Infarct Volume, cc | 0.970 (0.957,0.983) | <0.0001 | 1.041 (0.988,1.098) | 0.130 |
| Basal Ganglia Infarct Volume, cc | 0.916 (0.838,1.001) | 0.053 | 1.033 (0.866,1.233) | 0.717 |