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. 2021 Jan 30;105(4):1615–1627. doi: 10.1007/s00253-021-11133-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Comparison of the characterized secondary metabolism gene clusters in A. terreus strains. a Clustering of the A. terreus strains based on presence (blue tiles)/absence (gray tiles) of orthologs of A. terreus NIH 2624 core biosynthetic proteins involved in secondary metabolism, which were experimentally linked to their metabolic products in previous studies (as reviewed by Romsdahl and Wang 2019). Dendrogram was generated based on hierarchical clustering analysis. Y-axis: strain clustering; x-axis: protein clustering (dendrogram not shown). A. terreus T3 Kankrej was not included in the analysis due to unsatisfactory quality of its genome (high sequence fragmentation). b Comparison of lovastatin biosynthesis gene cluster conserved in five A. terreus genomes (gene names according to Dietrich and Vederas 2014)