Table 2.
Sensitivity, specificity, diagnostic accuracy, false negative and false positive cases relative to baseline NCCT, visually evaluated colour-coded MTT, CBV and CBF maps generated by CT Perfusion 4D software, visually evaluated colour-coded Tmax and CBF maps generated by RAPID software (Tmax1 and CBF1, respectively), automatic quantitative Tmax and CBF parameters spotted in the RAPID software-generated colour perfusion mismatch map (Tmax2 and CBF2, respectively)
| Parameters | Sensitivity (CI at 95%) | Specificity (CI at 95%) | Accuracy (CI at 95%) | False negative | False positive |
|---|---|---|---|---|---|
| Baseline NCCT | 29.6% (13/44) (16.8–45.2%) | 100% (6/6) (54.1–100%) | 38% (19/50) (25–52.7%) |
31/44 70.4% |
- |
| MTT (CT perfusion 4D) | 88.6% (39/44) (75.4–96.2%) | 50% (3/6) (11.8–88.2%) | 84% (42/50) (70.3–92.8%) |
5/44 11.4% |
3/6 50% |
| CBV (CT perfusion 4D) | 63.6% (28/44) (47.8–77.6%) | 100% (6/6) (54.1–100%) | 68% (34/50) (53.2–80.3%) |
16/44 36.4% |
- |
| CBF (CT perfusion 4D) | 81.8% (36/44) (67.3–91.8%) | 100% (6/6) (54.1–100%) | 84% (42/50) (70.3–92.8%) |
8/44 18.2% |
- |
| Tmax1 (colour-coded rapid) | 90.9% (40/44) (78.3–97.5%) | 66.7% (4/6) (22.3–95.7%) | 88% (44/50) (75–95.6%) |
4/44 9.1% |
2/6 33.3% |
| CBF1 (colour-coded rapid) | 61.4% (27/44) (45.5–75.6%) | 100% (6/6) (54.1–100%) | 66% (33/50) (51.1–78.6%) |
17/44 38.6% |
- |
| Tmax2 (quantitative rapid) | 65.9% (29/44) (50.1–79.5%) | 100% (6/6) (54.1–100%) | 70% (35/50) (55.2–81.9%) |
11/44 25% |
4/6 66.7% |
| CBF2 (quantitative Rapid) | 6.8% (3/44) (1.4–18.7%) | 100% (6/6) (54.1–100%) | 18% (9/50) (9.1–31.5%) |
41/44 93.2% |
- |
For each patient, follow-up CT or MRI was used as criterion standard. Confidence interval (CI) at 95%