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. 2020 Sep 8;268(2):651–657. doi: 10.1007/s00415-020-10210-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Overview of the study design of the ITT-PMS and the ITT-PMS extension trials. Treatment within the trials are marked with ‘RTX’. Month 12 was the last visit in the ITT-PMS trial and at the same time the first visit in the ITT-PMS extension trial with treatment according to the protocols of the extension trial. The reflex hammers indicate the timing of clinical evaluation. The scalpel indicates the insertion of the Ommaya reservoir. ITT-PMS Intrathecal Treatment Trial in Progressive Multiple Sclerosis, ITT-PMS ext Intrathecal Treatment Trial in Progressive Multiple Sclerosis extension, RTX rituximab