Table 3.
Results of the log-rank test of the Kaplan-Meier analysis for NCT03439332 cohort: (1) all, (2) moderate vascular (rCBVHAT < rCBVth), and (3) high vascular (rCBVHAT > rCBVth). For each subpopulation, the mean OS and number of patients with methylated MGMT and unmethylated MGMT are presented. Additionally, differences between OS (days), hazard ratios, area under the curve (AUC), and log-rank test resulting p value are presented
No. of patients | Median OS | |||||||
---|---|---|---|---|---|---|---|---|
Meth. MGMT | Unmeth. MGMT | Meth. MGMT | Unmeth. MGMT | ΔOS | HR [95% CI] | p | AUC | |
All | 43 | 53 | 507 | 373 | 134 | 2.10 [1.33–3.33] | 0.0016 | 0.61 |
Moderate rCBV | 19 | 29 | 678 | 411 | 267 | 2.73 [1.40–5.32] | 0.0031 | 0.70 |
High rCBV | 24 | 24 | 444 | 338 | 106 | 1.72 [0.90–3.27] | 0.10 | 0.56 |