Fig. 1. Odds ratios for at least nominally significant associations between cancer-specific polygenic risk scores (PRS) and cancer outcomes, based on meta-analyses of European ancestry participants from the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort and UK Biobank.

Odds ratios were estimated from logistic regression models, p values were calculated from two-sided Wald tests, and statistical significance (p < 0.05/16 = 0.0031) was determined accounting for multiple testing. Cancers are ordered based on hierarchical clustering of the odds ratios for each PRS across cancer outcomes.