Table 2.

Pattern of invasive disease-free survival events according to a type of BRCA-mutated gene.

	BRCA1 cohort N (%) n = 808	BRCA2 cohort N (%) n = 428	P valuea
Follow-up, median (IQR)	7.9 (5.4 to 10.6)	7.9 (6.0 to 10.6)	0.95
No events	492 (60.9)	262 (61.2)	0.76
Loco-regional recurrence	54 (6.7)	36 (8.4)	0.35
Distant recurrence ± loco-regional recurrence	84 (10.4)	66 (15.4)	0.02
Second primary malignancy	35 (4.3)	8 (1.9)	0.02
Ovarian cancer	18 (2.2)	1 (0.2)
Other	7 (0.9)	4 (0.9)
Missing	10 (1.2)	3 (0.7)
Second primary breast cancer	137 (17.0)	52 (12.2)	0.009
Death without any disease-free survival event	6 (0.7)	4 (0.9)	0.79

IQR interquartile range.

^aP-values for time-dependent events estimated by means of the Log-rank test.