Table 3.
Cox-regression analysis for determining risk factors associated with eGFR loss > 30%
| Variable | Hazard Ratio | 95% CI | P-value |
|---|---|---|---|
| Age at KTx | 1.134 | 1.023–1.058 | 0.017 |
| Previous KTx | 39.639 | 3.912–401.605 | 0.002 |
| CMV-viremia | 1.062 | 0.061–18.494 | 0.967 |
| BKV-viremia | 2.121 | 0.071–63.367 | 0.664 |
| Postmortal donation | 2.481 | 0.023–266.090 | 0.703 |
| NODAT | 0.919 | 0.067–12.537 | 0.949 |
| Time on dialysis | 1.010 | 0.982–1.038 | 0.502 |
| Cold ischemia time | 0.685 | 0.341–1.373 | 0.286 |
| Delayed graft function | 0.395 | 0.010–15.217 | 0.618 |
| Acute rejection | 4.057 | 0.708–23.259 | 0.116 |
| eGFR day 365 | 1.016 | 0.970–1.064 | 0.507 |
| UPCR day 365 | 1.000 | 1.000–1.001 | 0.277 |
| hs-CRP day 365 | 1.472 | 0.843–2.571 | 0.174 |
| BMI | 0.907 | 0.695–1.182 | 0.469 |
| HLA-mismatches | 0.379 | 0.141–1.018 | 0.054 |
| Number of antihypertensive agents day 365 | – | – | 0.480 |
| Mode of dialysis | – | – | 0.961 |
| Induction therapy | – | – | 0.108 |
| suPAR pre KTx | 1.000 | 1.000–1.000 | 0.370 |
| suPAR day 365 | 1.001 | 1.000–1.001 | < 0.001 |
*KTx kidney transplantation, CMV cytomegalovirus, BKV BK-polyomavirus, NODAT new onset of diabetes after transplantation, eGFR estimated glomerular filtration rate, UPCR urine protein/creatinine ratio, hs-CRP high sensitivity C-reactive protein, BMI body mass index, HLA human leukocyte antigen, suPAR soluble urokinase-type plasminogen activator receptor.