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. 2021 Feb 12;11:3768. doi: 10.1038/s41598-021-83234-9

Table 2.

Multivariate regression analysis to identify factors independently associated with the plasma XOR activity.

Model 1 Model 2 Model 3
Adjusted R2 Adjusted R2 Adjusted R2
R2 = 0.664 R2 = 0.642 R2 = 0.200
β p β p β p
Age 0.076 0.235 0.039 0.568 0.086 0.877
Sex − 0.073 0.262 − 0.079 0.211 − 0.155 0.104
BMI − 0.017 0.373 0.036 0.604 0.015 0.904
HbA1c − 0.055 0.622 − 0.037 0.559 0.012 0.909
UA 0.034 0.807 0.1 0.123 0.099 0.342
Fasting IRI 0.024 0.743 0.096 0.165 0.775 < 0.001
HOMA-IR − 0.019 0.785 0.047 0.468 − 0.43 0.019
TG 0.161 0.01 0.037 0.72
AST 0.365 0.003 0.325 0.011
ALT 0.465 < 0.001 0.509 < 0.001

Multiple regression analysis to determine factors independently associated with the plasma xanthine oxidase activity. Plasma xanthine oxidase activity was included as a dependent variable, and age, sex, body mass index, HbA1c, uric acid, fasting IRI and HOMA-IR were used as common explanatory variables.

We also included TG, AST and ALT as explanatory variables in model 1, AST and ALT in model 2, and TG in model 3.