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. Author manuscript; available in PMC: 2021 Feb 18.
Published in final edited form as: J Perinatol. 2020 Aug 13;41(2):255–262. doi: 10.1038/s41372-020-00784-y

Table 4.

Adverse outcomes in all VLBW infants

Period 1 n = 727 Period 2 n = 191 p-valuea

EOS (Culture confirmed infection at 0-3 days after birth), n (%) 9 (1.2) 2 (1.1) 0.83

 Hours from birth when culture obtainedb, Median (IQR) 0.6 (0.5-1.0) 1.1 (1.0-1.1) 0.41

 Hours from birth when first dose of antibiotic given, Median (IQR) 1.8 (1.4-2.1) 1.8 (1.6-2.0) 0.81

 Organisms, n -
  Escherichia coli 7 2
  Klebsiella pneumoniae 1 0
  Candida albicans 1 0

Culture confirmed infection at 4-7 days after birth, n (%) 15 (2.1) 3 (1.6) 0.66

 Hours from birth when culture obtained, Median (IQR) 138.2 (115.5-152.3) 137.1 (121.3-139.7) 0.59

 Hours from drawing culture and start of antibioticsc, Median (IQR) 0.8 (0.2-6.8) 1.0 (0.8-2.1) 0.77

 Organisms, n
  Coagulase-negative staphylococci 9 2d
  Escherichia coli 1 1
  Klebsiella pneumoniae 3 0
  Staphylococcus aureus 1 1
  Enterobacter cloacae 1 0

NEC/SIP ≤7 days after birth, n (%) 7 (1.0) 5 (2.6) 0.07

Indication for transfer ≤7 dayse, n (%) 17 (2.3) 6 (3.1) 0.53
 Anomalies 9 2
 NEC/SIP 7 4
 Respiratory management 1 0

Cause of death ≤7 daysf, n (%) 19 (2.6) 4 (2.1) 0.68
 Extreme prematurity and respiratory failure 12 3
 EOS 3 0
 Intracranial hemorrhage 3 0
 Other 1 1
a

χ2 analysis not done when cell value is zero.

b

One EOS infant in Period 1 had culture drawn at 65 hours for onset of SIP (excluded from median).

c

Two infants in Period 1 were being treated with antibiotics when blood culture was obtained: in the first case, for cellulitis, and blood culture grew same the bacteria as wound culture; and in the second case, the blood culture was for test of cure in the setting of prior bacteremia.

d

This infant also grew Staphylococcus aureus from blood culture has been counted in both.

e

All infants who were transferred at ≤7 days after birth had a blood culture obtained, and all except 1 infant in Period 2 (negative blood culture after birth) had empiric antibiotics initiated ≤3 days after birth.

f

All infants who died at ≤7 days after birth had a blood culture obtained and empiric antibiotics initiated ≤3 days after birth. EOS, early-onset sepsis; IQR, interquartile range; NEC, necrotizing enterocolitis; SIP, spontaneous intestinal perforation; VLBW, very low birth weight (birth weight <1,500 grams).