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Manhattan plots of stage-two SKAT-O gene-level associations with PCa. The x axes show the chromosomal positions and the y axes show the −log10 p value. (A) All PCa cases versus controls. (B) PCa cases with a positive family history versus controls. (C) Aggressive PCa cases versus controls. D) Aggressive PCa cases versus nonaggressive PCa cases. PCa = prostate cancer.
