Table 3 –

Aggressive cases: stage-two single-variant analyses that detected significant associations, illustrating the gene and summary statistics for variants

Gene ^a	rsID	Allele		Aggressive cases (N = 1258) vs controls (N = 1899)			Aggressive cases (N = 1258) vs Nonaggressive cases (N = 1659)			ALT allele frequency

		REF	ALT	OR	95% CI	p value	OR	95% CI	p value	Aggressive cases	Controls
EMSY	rs200165356	C	T	0.20	0.11, 0.36	1.68E-07	0.29	0.16, 0.55	1.00E-04	0.0056	0.0266
FAM114A1	rs754808360	C	T	0.35	0.27, 0.47	3.07E-13	0.40	0.30, 0.53	5.92E-10	0.0318	0.0882
	rs778907323	C	T	0.32	0.23, 0.43	1.35E-13	0.33	0.24, 0.46	7.88E-12	0.0250	0.0790
HOXB13	rs138213197	C	T	23.36	6.75, 80.87	6.56E-07	0.94	0.56, 1.58	0.81	0.0119	0.0008
MUC6	rs770247761	A	C	0.43	0.33, 0.57	6.35E-10	0.36	0.27, 0.47	1.19E-13	0.0362	0.0956
MYCBP2	rs374242789	TA	T	1.73	1.40, 2.13	3.12E-07	1.59	1.27, 1.99	4.37E-05	0.1222	0.0691
	rs751238365	T	TA	0.36	0.24, 0.53	3.76E-07	0.32	0.21, 0.48	3.19E-08	0.0146	0.0508
PRSS3	rs764430438	C	T	2.53	1.88, 3.42	1.21E-09	2.70	1.96, 3.73	1.41E-09	0.0656	0.0247
RAPGEF4	rs746414802	A	T	0.25	0.17, 0.36	4.88E-13	0.25	0.17, 0.37	2.16E-12	0.0151	0.0629
	rs758902129	C	T	0.30	0.20, 0.43	3.49E-10	0.28	0.19, 0.41	4.93E-11	0.0155	0.0569
	rs747279958	G	T	0.29	0.18, 0.46	2.41E-07	0.27	0.16, 0.43	5.74E-08	0.0099	0.0377
RNASEH2B	rs1172291060	C	T	0.50	0.38, 0.66	7.74E-07	0.53	0.39, 0.71	2.08E-05	0.0335	0.0795
THAP3 (603 bp)	rs1369585326	C	T	0.48	0.37, 0.64	3.50E-07	0.40	0.30, 0.53	1.34E-10	0.0338	0.0764
THAP3 (600 bp)	rs1228553175	C	T	0.39	0.27, 0.56	2.64E-07	0.35	0.24, 0.50	7.57E-09	0.0187	0.0529
ULK4	rs202114865	G	A	0.34	0.25, 0.46	1.52E-11	0.40	0.29, 0.55	4.67E-08	0.0231	0.0796
XPO7	rs771633865	C	T	0.32	0.23, 0.45	3.70E-11	0.39	0.27, 0.55	7.70E-08	0.0219	0.0706
	rs760440285	G	T	0.29	0.21, 0.41	2.37E-12	0.33	0.23, 0.47	1.13E-09	0.0191	0.0690

CI = confidence interval; OR = odds ratio.

Variants outside a gene have their base-pair distance to the nearest gene in parentheses based on Genome Reference Consortium Human Build 38.