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. 2021 Feb 12;7:11. doi: 10.1038/s41523-021-00222-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Forest plots of PFS, OS, DoCB and CBR. Data for VLM are not available for the EORTC trial. *Fixed effect for trial was fitted in all models. †Random effect for trial were fitted in model for AI. ‡OS data for Study 0027 are based on aggregated mature survival data. b Projected probability of PFS, OS and DoCB. Median (95% CI) PFS/OS/DoCB in months. AI aromatase inhibitor, CBR clinical benefit rate, DoCB duration of clinical benefit, HR hazard ratio, n number of patients, non-VM non-visceral metastases, PFS progression-free survival, OR odds ratio, OS overall survival, SERD selective estrogen receptor degrader, SERM selective estrogen receptor modulator, VLM visceral liver metastases, VM visceral metastases, VnLM visceral non-liver metastases. Statistics for full models: VLM vs VnLM PFS: SERM: p = 0·005, heterogeneity test p = 0·91; AI: p = 0·008, heterogeneity test p = 0·81; SERD: p < 0.001, heterogeneity test p = 0·95; All: p < 0·001, heterogeneity test p = 0·99. OS: SERM: p = 0·020, heterogeneity test p = 0·89; AI: p = 0·106, heterogeneity test p < 0·05; SERD: p < 0.001, heterogeneity test p = 0·34; All: p < 0·001, heterogeneity test p = 0·24. DoCB: SERM: p = 0·255, heterogeneity test p = 0·93; AI: p = 0·229, heterogeneity test p = 1·00; SERD: p < 0·001, heterogeneity test p = 0·08; All: p = 0·001, heterogeneity test p = 0·58. CBR: SERM: p = 0·077, heterogeneity test p = 0·72; AI: p = 0·008, heterogeneity test p = 0·43; SERD: p = 0·012, heterogeneity test p = 0·43; All: p < 0·001, heterogeneity test p = 0·80.