Table 2.
Characteristics of the dogs at baseline.
| Characteristic | |
|---|---|
| Age—year | |
| Median | 13 |
| Range | 8–16 |
| Age category―no. (%) | |
| ≥10 year | 27 (93.1) |
| <10 year | 2 (6.9) |
| Sex―no. (%) | |
| Male | |
| Intact | 8 (27.6) |
| Castrated | 11 (37.9) |
| All | 19 (65.5) |
| Female | |
| Intact | 3 (10.3) |
| Spayed | 7 (24.1) |
| All | 10 (34.5) |
| PD-L1 status—no. (%) | |
| Positive | |
| TPS ≥ 50% | 18 (62.1) |
| TPS 1–49% | 1 (3.4) |
| TPS ND | 7 (24.1) |
| All | 26 (89.7) |
| Negative (TPS < 1%) | 2 (6.9) |
| ND | 1 (3.4) |
| Prior therapy―no. (%) | |
| Surgery | 17 (58.6) |
| Radiation | |
| ≤8 weeksa | 8 (27.6) |
| >8 weeks | 4 (13.8) |
| Unknown | 2 (6.9) |
| All | 14 (48.3) |
| Chemotherapy | 1 (3.4) |
| None | 2 (6.9) |
| Measurable lesion(s)―no. (%) | |
| Present | 13 (44.8) |
| Absent | 16 (55.2) |
TPS tumor proportion score, ND not determined.
aDogs that received previous radiation ≤8 weeks before the first dose of c4G12.