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. 2021 Feb 12;12:1013. doi: 10.1038/s41467-021-21129-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Coomassie-stained denaturing protein gels of ex vivo AA amyloid fibrils and in vitro formed SAA1.1 fibrils that were incubated with different proteases for up to 300 min: proteinase K (a, n = 3) and three other proteases (pronase E (b), leucine aminopeptidase (c) and carboxypeptidase A (d), n = 1). Bands above 14 kDa originate from the proteases. Due to the harsh proteolytic conditions used in this experiment there is discernible degradation of in vitro fibrils during sample workup for electrophoresis (0 min), specifically with proteinase K and pronase E.