Table 2.
The NOTCH1 pathway is activated in human oligodendrogliomas compared to glioblastomas.
| Molecular human glioblastoma vs. molecular human oligodendroglioma | ||||
|---|---|---|---|---|
| NOTCH1 pathway activation | ||||
| Gene | Entrez ID | log2 fold change | p value | FDR |
| SOX8 | 30812 | −2.5180613 | 5.39E−43 | 5.67E−41 |
| DLL3 | 10683 | −2.4262425 | 1.26E−17 | 1.33E−16 |
| HEY1 | 23462 | −1.2942635 | 9.18E−23 | 1.53E−21 |
| MYC | 4609 | −1.2213157 | 3.76E−15 | 3.05E−14 |
| HES6 | 55502 | −1.1642784 | 1.29E−08 | 5.07E−08 |
| DLL1 | 28514 | −1.0985485 | 9.11E−08 | 3.25E−07 |
| SATB1 | 6304 | −0.8875692 | 5.68E−11 | 2.92E−10 |
| ZMIZ1 | 57178 | −0.8720752 | 7.95E−17 | 7.77E−16 |
| NOTCH1 | 4851 | −0.5352691 | 5.91E−05 | 0.00014523 |
| CDKN1B | 1027 | −0.4286673 | 2.34E−09 | 1.00E−08 |
| CCND1 | 595 | −0.3288129 | 0.12248947 | 0.16628677 |
| ASCL1 | 429 | −0.2774871 | 0.1584482 | 0.20949394 |
| CDKN1A | 1026 | −0.1732208 | 0.40000144 | 0.46701398 |
| PTPRJ | 5795 | −0.1423327 | 0.20323507 | 0.26025615 |
| JAG1 | 182 | 1.45417948 | 3.46E−21 | 4.94E−20 |
| NOTCH1 pathway inhibition | ||||
|---|---|---|---|---|
| Gene | Entrez ID | log2 fold change | p value | FDR |
| CHI3L1 | 1116 | 5.41391741 | 2.64E−35 | 1.46E−33 |
| NUMB | 8650 | 0.6442456 | 1.12E−19 | 1,46E−18 |
Comparison of RNA expression data (TCGA) of molecular glioblastoma (n = 56) and molecular 1p/19q-codeleted oligodendroglioma (n = 70) reveals downregulation of genes associated with NOTCH1 pathway activation in glioblastoma and upregulation of genes associated with NOTCH1 pathway inhibition.
FDR False discovery rate.