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. 2021 Feb 12;11:3727. doi: 10.1038/s41598-021-81796-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Sub-group analysis of individual markers based on histological subtype. (A) Tree network showing number of studies for each marker per outcome group, analysis method and histological subtype. Figure generated using the vtree package in R (version 3.5.2). (B) Random-effect forest plots of individual markers from the OS/DSS outcome group and univariate analysis method with histological subtype indicated.