Table 4.
Summary of results from the random effects models for each cellular process. The list of proteins making up each cellular process can be found in Table 3.
| Cellular process | Studies | Random effects model | Heterogeneity | |||
|---|---|---|---|---|---|---|
| Overall effect (95% CIs) | P value | I2 (%) | τ2 | P value | ||
| Generation and maintenance of CAF phenotype | 6 | 2.25 (1.27–4.00) | 0.006 | 81 | 0.36 | < 0.01 |
| Re-modelling of extracellular matrix | 10 | 1.86 (1.45–2.40) | < 0.001 | 41 | 0.07 | 0.08 |
| Immunosuppression | 6 | 1.77 (1.17–2.67) | 0.007 | 63 | 0.16 | 0.02 |
| Promoting migration and invasion of tumour cells | 13 | 1.77 (1.41–2.12) | < 0.001 | 46 | 0.07 | 0.04 |
| Promoting tumour angiogenesis | 4 | 1.57 (1.30–1.89) | < 0.001 | 0 | 0.00 | 0.50 |
| Enhancing proliferation and survival of tumour cells | 7 | 2.06 (1.25–3.40) | 0.005 | 85 | 0.34 | < 0.01 |
| Metabolic regulation of tumour cells | 2 | 1.38 (1.08–1.77) | 0.010 | 20 | 0.01 | 0.26 |