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. 2021 Feb 12;7:10. doi: 10.1038/s41540-021-00170-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Contribution of each of the 56 effectors to Ras binding was analyzed according to a 5%-complex-formation threshold, both for the unstimulated and the stimulated Ras network. Each effector forming a complex for at least 5%, in the unstimulated case, was classified in Group 1; if this happened in the stimulated case (according to the results from global sensitivity), it entered Group 2; otherwise it fed into the last group. – Group 1: efficient Ras-effector complex formation with RBD. Group 2: efficient Ras-effector complex formation with RBD and additional domains recruited to the plasma membrane. Group 3: inefficient Ras-effector complex formation.