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. 2021 Feb 12;12:979. doi: 10.1038/s41467-021-21204-5

Fig. 6. Pharmacological inhibition of PRMT5 significantly extends survival of mice with orthotopic xenografts of GSCs.

Fig. 6

a Concentration of LLY-283 in the plasma and brain of NSG mice 24 h after oral administration of 25, 50, and 100 mg/kg of LLY-283. n = 3, mean ± SD. b Kaplan–Meier survival curve of immunodeficient NSG mice injected intracranially with G411 GSCs and treated with 50 mg/kg LLY-283 (Vehicle: n = 10; LLY-283: n = 12). Significance was estimated using the log-rank (Mantel–Cox) test (two sided). Chi square = 8.038, p value = 0.0046. c H&E staining of a mouse brain with orthotopic xenografts treated with LLY-283 or vehicle at end point (scale bar = 1000 μm). N = 5 for LLY-283, N = 2 for vehicle. d Representative western blot of symmetric dimethyl arginine mark in tumor tissue from mice with orthotopic xenografts treated with LLY-283 or vehicle at experimental end point. The experiment was repeated twice with similar results. See also Supplementary Fig. 5. Source data are provided as a Source data file.