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. 2021 Feb 12;11:3731. doi: 10.1038/s41598-021-82172-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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⁹⁰Y-DOTA-αGPC3 RIT decreases tumor burden—(a) Serum AFP measurements in untreated (n = 11), non-radiolabeled αGPC3-DOTA treated (n = 12) and ⁹⁰Y-DOTA-αGPC3 treated (n = 12) mice and (b) GTV measurements by ⁸⁹Zr-DFO-αGPC3 immuno-PET in untreated (n = 10 pre-RIT, n = 9 post-RIT), non-radiolabeled αGPC3-DOTA treated (n = 9 pre-RIT, n = 10 post-RIT) and ⁹⁰Y-DOTA-αGPC3 RIT treated (n = 10 pre-RIT, n = 11 post-RIT) mice before (day 0) and 30 days after therapy. Bar represents mean. Normality of data assessed via Shapiro Statistical analysis by One. Kruskal–Wallis with Dunn’s multiple comparison test was performed for pairwise comparisons. * denotes p < 0.05.