Table 3. KEGG pathway analysis based on EC–POI network (top 20 with P-value).

ID	Pathway	Genes	n	P-value
hsa04668	TNF signaling pathway	PIK3CG, AKT1, CSF2, CASP3, IL6, TNF, CCL2, CEBPB, PTGS2, JUN, CREB1	11	1.06 × 10−8
hsa04915	Estrogen signaling pathway	PIK3CG, AKT1, HSP90AA1, HSPA2, JUN, CREB1, ESR1, ESR2, SRC	9	1.11 × 10−6
hsa04919	Thyroid hormone signaling pathway	ACTB, PRKCA, PIK3CG, AKT1, NCOA1, RXRA, ESR1, SRC, PRKCB	9	3.48 × 10−6
hsa04370	VEGF signaling pathway	PRKCA, PIK3CG, AKT1, PTGS2, VEGFA, SRC, PRKCB	7	8.70 × 10−6
hsa04066	HIF-1 signaling pathway	PRKCA, PIK3CG, AKT1, IL6, HMOX1, VEGFA, PRKCB	7	1.17 × 10−4
hsa04664	Fcϵ RI signaling pathway	PRKCA, PIK3CG, AKT1, CSF2, TNF, PRKCB	6	2.10 × 10−4
hsa04015	Rap1 signaling pathway	ACTB, PRKCA, PIK3CG, AKT1, CNR1, VEGFA, GRIN1, SRC, PRKCB	9	2.66 × 10−4
hsa04151	PI3K-Akt signaling pathway	PRKCA, PIK3CG, AKT1, IL6, HSP90AA1, RXRA, CREB1, VEGFA, JAK1, CDK6, IL2	11	3.98 × 10−4
hsa04012	ErbB signaling pathway	PRKCA, PIK3CG, AKT1, JUN, SRC, PRKCB	6	6.63 × 10−4
hsa05166	HTLV-I infection	PIK3CG, AKT1, CSF2, IL6, TNF, JUN, CREB1, JAK1, IL2	9	9.45 × 10−4
hsa04150	mTOR signaling pathway	PRKCA, PIK3CG, AKT1, TNF, PRKCB	5	1.21 × 10−3
hsa04660	T cell receptor signaling pathway	PIK3CG, AKT1, CSF2, TNF, JUN, IL2	6	1.24 × 10−3
hsa04510	Focal adhesion	ACTB, PRKCA, PIK3CG, AKT1, JUN, VEGFA, SRC, PRKCB	8	1.30 × 10−3
hsa05321	Inflammatory bowel disease (IBD)	IL6, TNF, JUN, IL1A, IL2	5	1.74 × 10−3
hsa05214	Glioma	PRKCA, PIK3CG, AKT1, CDK6, PRKCB	5	1.85 × 10−3
hsa05145	Toxoplasmosis	AKT1, CASP3, TNF, HSPA2, JAK1, ALOX5	6	1.91 × 10−3
hsa04917	Prolactin signaling pathway	PIK3CG, AKT1, ESR1, ESR2, SRC	5	2.55 × 10−3
hsa04071	Sphingolipid signaling pathway	PRKCA, PIK3CG, AKT1, TNF, ABCC1, PRKCB	6	2.79 × 10−3
hsa04650	Natural killer cell-mediated cytotoxicity	PRKCA, PIK3CG, CSF2, CASP3, TNF, PRKCB	6	3.00 × 10−3
hsa04010	MAPK signaling pathway	PRKCA, AKT1, CASP3, TNF, HSPA2, JUN, IL1A, PRKCB	8	4.16 × 10−3