Table 1.
Relative abundance of major myelin proteins by mass spectrometric quantification.
| myelin protein | CNS myelin (%) [60] | PNS myelin (%) [61] | associated disease | effect on myelination |
|---|---|---|---|---|
| proteolipid protein (Plp1) | 17 | 0.2 | Pelizaeus–Merzbacher disease; spastic paraplegia type 2 | hypomyelinating leukodystrophy |
| myelin basic protein (Mbp) | 8 | 8 | 18q deletion syndrome | dysmyelination |
| myelin protein zero (P0) | ND | 21 | Charcot–Marie–Tooth neuropathy | hypomyelinating neuropathy |
| periaxin (Prx) | ND | 16 | Charcot–Marie–Tooth neuropathy | hypomyelinating neuropathy |
| cyclic nucleotide phosphodiesterase (Cnp) | 4 | 0.5 | catatonia-depression syndrome upon aging | white matter neuroinflammation |
| myelin-associated glycoprotein (Mag) | 1 | 0.3 | autoantibody-mediated neuropathy | — |
| myelin oligodendrocyte glycoprotein (Mog) | 1 | ND | narcolepsy 7 | — |
| sirtuin 2 (Sirt2) | 1 | ND | NA | NA |
| Claudin 11 (Cldn11) | 1 | ND | NA | NA |
| fatty acid synthase (Fasn) | 1 | ND | NA | NA |
| Band 4.1-like protein G (Epb4.1l2) | ND | 1 | NA | NA |
| others | 67 | 52 | — | — |