Table 2.
Clinical features of head & neck angiosarcoma (AS-HN) compared to other sites.
| Characteristic (n) | Tumor site | p | |
|---|---|---|---|
| AS-HN | Other | ||
| Total (150) | 88 (58.7%) | 62 (41.3%) | – |
| Sex | 0.0192 | ||
| Male (94) | 62 (66.0%) | 32 (34.0%) | |
| Female (56) | 26 (46.4%) | 30 (53.6%) | |
| Age at diagnosis (years) | <0.0001 | ||
| >65 (83) | 67 (80.7%) | 16 (19.3%) | |
| ≤65 (67) | 21 (31.3%) | 46 (68.7%) | |
| Ethnicity | 0.156 | ||
| Chinese (124) | 76 (61.3%) | 48 (38.7%) | |
| Other (26) | 12 (46.2%) | 14 (53.8%) | |
| Performance status (ECOG score) | 0.118 | ||
| 0 (70) | 36 (51.4%) | 34 (48.6%) | |
| 1–4 (73) | 47 (64.4%) | 26 (35.6%) | |
| Cardiovascular co-morbidities† | <0.0001 | ||
| Present (90) | 65 (72.2%) | 25 (27.8%) | |
| Absent (60) | 23 (38.3%) | 37 (61.7%) | |
| Etiology | <0.0001 | ||
| Primary (132) | 87 (65.9%) | 45 (34.1%) | |
| Secondary (18) | 1 (5.6%) | 17 (94.4%) | |
| Cutaneous origin | <0.0001 | ||
| Yes (90) | 83 (92.2%) | 7 (7.8%) | |
| No (60) | 5 (8.3%) | 55 (91.7%) | |
| Epithelioid component | 0.393 | ||
| Present (59) | 29 (49.2%) | 30 (50.8%) | |
| Absent (56) | 32 (57.1%) | 24 (42.9%) | |
| Distant metastasis at diagnosis | 0.0365 | ||
| Present (60) | 29 (48.3%) | 31 (51.7%) | |
| Absent (90) | 59 (65.6%) | 31 (34.4%) | |
†Includes hypertension, hyperlipidemia, diabetes mellitus, ischemic heart disease, cerebrovascular disease.
Data unavailable for ECOG score (n = 7), histomorphology (n = 35).