Table 4.
Clinical relevance and certainty of evidence provided by statistical difference in clinical and pathologic endpoints (dichotomous and numeric) between robotic vs. open pancreaticoduodenectomy.
| Dichotomous endpoints | RRR | ARR (95%CI) | NNT (95%CI) | 95% prediction interval | GRADE certainty of evidence |
|---|---|---|---|---|---|
| Postoperative overall morbidity | 0.22 | 0.118 (0.086, 0.149) | 9 (7, 12) | 0.72, 1.02 |
Moderate ⊕⊕⊕◯ |
| POPF rate | 0.13 | 0.021 (0.004, 0.038) | 47 (26, 267) | 0.29, 2.74 |
Low ⊕⊕◯◯ |
| DGE rate | 0.03 | 0.005 (− 0.017, 0.026) | 210 (> 38 to benefit, > 4 to harm) | 0.51, 1.87 |
Very low ⊕◯◯◯ |
| Incisional SSI rate | 0.22 | 0.022 (0.004, 0.040) | 46 (25, 243) | 0.12, 1.70 |
Low ⊕⊕◯◯ |
| Reoperation rate | 0.01 | 0.000 (− 0.013, 0.014) | 3,007 (> 76 to harm, > 72 to benefit) | 0.61, 1.04 |
Very low ⊕◯◯◯ |
| Margin involvement rate | 0.22 | 0.044 (0.013, 0.075) | 23 (13, 79) | 0.15, 2.68 |
Moderate ⊕⊕⊕◯ |
| Numeric endpoints | MD (95% CI) | Clinical importance of the MD | 95% prediction interval | GRADE certainty of evidence | |
|---|---|---|---|---|---|
| Operating time | 75.17 (48.05, 102.28) | Moderate | − 58.77, 209.11 |
Low ⊕⊕◯◯ |
|
| Estimated blood loss | − 191.35 (− 238.12, − 144.59) | Low | − 382.04, − 0.66 |
Moderate ⊕⊕⊕◯ |
|
| Length of hospital stay | − 1.00 (− 1.88, − 0.12) | Moderate | − 4.32, 2.32 |
Very low ⊕◯◯◯ |
|
| Number of lymph nodes harvested | 2.88 (1.12, 4.65) | Moderate | − 3.97, 9.73 |
Low ⊕⊕◯◯ |
|
RRR relative risk reduction; ARR absolute risk reduction; NNT numbers needed to treat; 95%CI 95% confidence interval; POPF postoperative pancreatic fistula; DGE delayed gastric emptying; SSI surgical site infection; MD mean difference.